Listar por autor "Andrés Benito, Pol"
Mostrando ítems 1-7 de 7
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Amyotrophic lateral sclerosis is accompanied by protein derangements in the olfactory bulb-tract axis
Lachén Montes, Mercedes ; Mendizuri, Naroa; Ausín, Karina; Andrés Benito, Pol; Ferrer, Isidro; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (MDPI, 2020) Artículo / ArtikuluaAmyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis ... -
Deregulated transcription and proteostasis in adult mapt knockout mouse
Andrés Benito, Pol; Flores, África; Busquet-Areny, Sara; Carmona, Margarita; Ausín, Karina; Cartas Cejudo, Paz; Lachén Montes, Mercedes ; Río, José Antonio del; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2023) Artículo / ArtikuluaTranscriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn about the effects of tau ablation. Compared with ... -
Dysregulated protein phosphorylation: a determining condition in the continuum of brain aging and Alzheimer's disease
Ferrer, Isidro; Andrés Benito, Pol; Ausín, Karina; Pamplona, Reinald; Río, José Antonio del; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Wiley, 2021) Artículo / ArtikuluaTau hyperphosphorylation is the first step of neurofibrillary tangle (NFT) formation. In the present study, samples of the entorhinal cortex (EC) and frontal cortex area 8 (FC) of cases with NFT pathology classified as ... -
Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy
Ferrer, Isidro; Andrés Benito, Pol; Zelaya Huerta, María Victoria ; Erro Aguirre, María Elena; Carmona, Margarita; Ausín, Karina; Lachén Montes, Mercedes ; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Río, José Antonio del (Springer, 2020) Artículo / ArtikuluaGlobular glial tauopathy (GGT) is a progressive neurodegenerative disease involving the grey matter and white matter (WM) and characterized by neuronal deposition of hyper-phosphorylated, abnormally conformed, truncated, ... -
Host tau genotype specifically designs and regulates tau seeding and spreading and host tau transformation following intrahippocampal injection of identical tau AD inoculum
Andrés Benito, Pol; Carmona, Margarita; Jordán, Mónica; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Río, José Antonio del; Ferrer, Isidro (MDPI, 2022) Artículo / ArtikuluaSeveral studies have demonstrated the different characteristics of tau seeding and spreading following intracerebral inoculation in murine models of tau-enriched fractions of brain homogenates from AD and other tauopathies. ... -
Increased C-X-C motif chemokine ligand 12 levels in cerebrospinal fluid as a candidate biomarker in sporadic amyotrophic lateral sclerosis
Andrés Benito, Pol; Povedano, Mónica; Domínguez Rubio, Raúl; Marco, Carla; Colomina, María J.; López-Pérez, Óscar; Santana, Isabel; Baldeiras, Inês; Martínez-Yelámos, Sergio; Zerr, Inga; Llorens, Franc; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2020) Artículo / ArtikuluaSporadic amyotrophic lateral sclerosis (sALS) is a fatal progressive neurodegenerative disease affecting upper and lower motor neurons. Biomarkers are useful to facilitate the diagnosis and/or prognosis of patients and to ... -
Proteostatic modulation in brain aging without associated Alzheimer's disease-and age-related neuropathological changes
Andrés Benito, Pol; Íñigo-Marco, Ignacio; Brullas, Marta; Carmona, Margarita; Del Rio, José Antonio; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Povedano, Mónica; Ferrer, Isidro (Impact Journals, 2023) Artículo / ArtikuluaAims: (Phospho)proteomics of old-aged subjects without cognitive or behavioral symptoms, and without ADneuropathological changes and lacking any other neurodegenerative alteration will increase understanding about the ...